In this document, we carefully defined the concept of OOTL and reviewed the different works associated. We also investigated current solutions proposed to mitigate its effect. Finally, we proposed a review of the different markers associated to vigilance decrement, one of the main illustration of the OOTL phenomenon. We particularly focused on biological markers as basement for future development of our vigilance/attentional observer. Documents regarded ethical requirements have also been completed and a final version of our Project Management Plan was delivered.